Detailed view for Bm1_13540

Basic information

TDR Targets ID: 235340
Brugia malayi, AT21637p
Source Database / ID:  GenBank

pI: 8.7997 | Length (AA): 276 | MW (Da): 31841 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05301   GNAT acetyltransferase, Mec-17

Gene Ontology

Mouse over links to read term descriptions.
GO:0071929   GO:alpha-tubulin acetylation  

GO:0019799   tubulin N-acetyltransferase activity  
GO:0005874   microtubule  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 189 4b5o (A) 1 194 35.00 0 1 1.07266 -0.51
2 186 4h6z (A) 1 185 44.00 0 1 0.83879 0.82
5 185 4hkf (A) 4 184 42.00 0 1 1.1596 -0.51
38 185 4h6u (A) 16 184 39.00 0 1 1.05833 -0.81
181 227 2n72 (A) 22 68 15.00 0 0 0.39839 -0.93
215 245 5d60 (A) 171 201 29.00 0 0.01 0.507419 -1.19

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_129810)

Species Accession Gene Product
Brugia malayi Bm1_13540   AT21637p
Caenorhabditis elegans CELE_W06B11.1   Protein ATAT-2
Caenorhabditis elegans CELE_F57H12.7   Protein MEC-17
Drosophila melanogaster Dmel_CG17003   CG17003 gene product from transcript CG17003-RA
Drosophila melanogaster Dmel_CG3967   CG3967 gene product from transcript CG3967-RC
Echinococcus granulosus EgrG_000075600   alpha tubulin N acetyltransferase
Echinococcus multilocularis EmuJ_000075600   alpha tubulin N acetyltransferase
Giardia lamblia GL50803_16348   Mechanosensory abnormality MEC-17-like protein
Homo sapiens ENSG00000137343   alpha tubulin acetyltransferase 1
Leishmania braziliensis LbrM.25.1130   hypothetical protein, conserved
Leishmania donovani LdBPK_251190.1   hypothetical protein, conserved
Leishmania infantum LinJ.25.1190   hypothetical protein, conserved
Leishmania major LmjF.25.1150   hypothetical protein, conserved
Leishmania mexicana LmxM.25.1150   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_13260   hypothetical protein
Mus musculus ENSMUSG00000024426   alpha tubulin acetyltransferase 1
Neospora caninum NCLIV_010560   hypothetical protein, conserved
Plasmodium falciparum PF3D7_0924900   alpha-tubulin N-acetyltransferase, putative
Plasmodium knowlesi PKNH_0722800   alpha-tubulin N-acetyltransferase, putative
Plasmodium vivax PVX_099660   alpha-tubulin N-acetyltransferase, putative
Schistosoma japonicum Sjp_0201960   IPR007965,Protein of unknown function DUF738,domain-containing
Schmidtea mediterranea mk4.005441.00  
Trypanosoma brucei gambiense Tbg972.3.1150   hypothetical protein, conserved
Trypanosoma brucei Tb927.3.1400   alpha-tubulin N-acetyltransferase, putative
Trypanosoma congolense TcIL3000_3_620   alpha-tubulin N-acetyltransferase, putative
Trypanosoma cruzi TcCLB.509233.160   alpha-tubulin N-acetyltransferase, putative
Trypanosoma cruzi TcCLB.467287.10   alpha-tubulin N-acetyltransferase, putative
Toxoplasma gondii TGME49_319600   alpha-tubulin N-acetyltransferase, putative
Trichomonas vaginalis TVAG_290890   conserved hypothetical protein
Trichomonas vaginalis TVAG_212520   conserved hypothetical protein

Essentiality

Bm1_13540 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.3.1400 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.3.1400 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.3.1400 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.3.1400 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
TGME49_319600 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier Bm1_13540 (Brugia malayi), AT21637p
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